Currently there is no way to set column specific settings on the layout without some rather complex and not neat solutions.
Examples would be you one row to have different font, or different background colour/image.
Currently these settings would have to be bundled into the layout which is cumbersome as its unknown how many columns the layout has when showing the settings.
Being able to define a blueprint to use at layout level would be great here.
This appears to be a trouble point for a few people from what I have seen.